Strange Bedfellows: Reelin and Notch Signaling Interact to Regulate Cell Migration in the Developing Neocortex
نویسنده
چکیده
Neuronal cell migration in the developing neocortex relies on the Reelin signaling cascade to establish the characteristic "inside out" lamination pattern. In this issue of Neuron, Rakic and colleagues report that Notch signaling, long known to regulate neural stem cells, also plays a critical role in mediating the effects of Reelin on neuronal cell migration.
منابع مشابه
Interaction between Reelin and Notch Signaling Regulates Neuronal Migration in the Cerebral Cortex
Neuronal migration is a fundamental component of brain development whose failure is associated with various neurological and psychiatric disorders. Reelin is essential for the stereotypical inside-out sequential lamination of the neocortex, but the molecular mechanisms of its action still remain unclear. Here we show that regulation of Notch activity plays an important part in Reelin-signal-dep...
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ورودعنوان ژورنال:
- Neuron
دوره 60 شماره
صفحات -
تاریخ انتشار 2008